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Luttrell, Louis
One or more keywords matched the following items that are connected to Luttrell, Louis
Item TypeName
Academic Article Regulation of mitogen-activated protein kinase pathways by catecholamine receptors.
Academic Article G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors.
Academic Article Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.
Academic Article G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases.
Academic Article Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.
Academic Article Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.
Academic Article Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
Academic Article The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism.
Academic Article Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases.
Academic Article Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases.
Academic Article Pasteurella multocida toxin stimulates mitogen-activated protein kinase via G(q/11)-dependent transactivation of the epidermal growth factor receptor.
Academic Article Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.
Academic Article The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor.
Academic Article Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells.
Academic Article Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation.
Academic Article Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity.
Academic Article Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding.
Academic Article A pertussis toxin-sensitive G-protein mediates some aspects of insulin action in BC3H-1 murine myocytes.
Academic Article G protein-coupled receptors desensitize and down-regulate epidermal growth factor receptors in renal mesangial cells.
Academic Article beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation.
Academic Article Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor.
Academic Article Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.
Academic Article Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling.
Academic Article Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis.
Academic Article Regulation of tyrosine kinase cascades by G-protein-coupled receptors.
Academic Article Activation of extracellular signal-regulated kinase in human prostate cancer.
Academic Article Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.
Academic Article Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways.
Academic Article Signaling in time and space: G protein-coupled receptors and mitogen-activated protein kinases.
Academic Article Not so strange bedfellows: G-protein-coupled receptors and Src family kinases.
Academic Article Mitogenic signaling in androgen sensitive and insensitive prostate cancer cell lines.
Academic Article beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis.
Academic Article Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.
Academic Article 5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells.
Academic Article Transmembrane signaling by G protein-coupled receptors.
Academic Article Identification of a putative nuclear localization sequence within ANG II AT(1A) receptor associated with nuclear activation.
Academic Article Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.
Academic Article New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades.
Academic Article G protein-coupled receptor signaling complexity in neuronal tissue: implications for novel therapeutics.
Academic Article Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation.
Academic Article Heptahelical terpsichory. Who calls the tune?
Academic Article The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth.
Academic Article beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport.
Academic Article The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals.
Academic Article Angiotensin II-induced cyclooxygenase 2 expression in rat aorta vascular smooth muscle cells does not require heterotrimeric G protein activation.
Academic Article Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders.
Academic Article A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.
Academic Article Beyond desensitization: physiological relevance of arrestin-dependent signaling.
Academic Article Genetic variant in the promoter of connective tissue growth factor gene confers susceptibility to nephropathy in type 1 diabetes.
Academic Article Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors.
Academic Article Brave new world? Arrestin pathway bias in drug design.
Academic Article Increased expression of beta-arrestin 1 and 2 in murine models of rheumatoid arthritis: isoform specific regulation of inflammation.
Academic Article Refining efficacy: exploiting functional selectivity for drug discovery.
Academic Article Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells.
Academic Article Functional signaling biases in G protein-coupled receptors: Game Theory and receptor dynamics.
Academic Article Biasing the parathyroid hormone receptor: relating in vitro ligand efficacy to in vivo biological activity.
Academic Article Emergent biological properties of arrestin pathway-selective biased agonism.
Academic Article The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.
Academic Article 'Location, location, location': activation and targeting of MAP kinases by G protein-coupled receptors.
Academic Article Arrestin pathways as drug targets.
Academic Article Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.
Academic Article Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation.
Academic Article Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway.
Academic Article Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling.
Academic Article Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.
Academic Article Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor.
Academic Article Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors.
Academic Article G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.
Academic Article Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway.
Academic Article Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases.
Academic Article Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation.
Academic Article Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
Academic Article Ectodomain shedding-dependent transactivation of epidermal growth factor receptors in response to insulin-like growth factor type I.
Academic Article Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.
Academic Article The origins of diversity and specificity in g protein-coupled receptor signaling.
Academic Article Composition and function of g protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity.
Academic Article beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.
Academic Article Arrestin-mediated ERK activation by gonadotropin-releasing hormone receptors: receptor-specific activation mechanisms and compartmentalization.
Academic Article Constitutive ERK1/2 activation by a chimeric neurokinin 1 receptor-beta-arrestin1 fusion protein. Probing the composition and function of the G protein-coupled receptor "signalsome".
Academic Article Signal switching, crosstalk, and arrestin scaffolds: novel G protein-coupled receptor signaling in cardiovascular disease.
Academic Article Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors.
Academic Article Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression.
Academic Article The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells.
Academic Article Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcription.
Academic Article Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.
Academic Article c-Src-mediated phosphorylation of AP-2 reveals a general mechanism for receptors internalizing through the clathrin pathway.
Academic Article Diversity in arrestin function.
Academic Article Bradykinin decreases podocyte permeability through ADAM17-dependent epidermal growth factor receptor activation and zonula occludens-1 rearrangement.
Academic Article Novel mechanisms in the regulation of G protein-coupled receptor trafficking to the plasma membrane.
Academic Article Insulin and phorbol ester induce distinct phosphorylations of pp60c-src in the BC3H-1 murine myocyte cell line.
Academic Article The beta-arrestin pathway-selective type 1A angiotensin receptor (AT1A) agonist [Sar1,Ile4,Ile8]angiotensin II regulates a robust G protein-independent signaling network.
Academic Article Refining efficacy: allosterism and bias in G protein-coupled receptor signaling.
Academic Article Phospholipase C and protein kinase C-? 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation.
Academic Article ?-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo.
Academic Article A high-content, live-cell, and real-time approach to the quantitation of ligand-induced ?-Arrestin2 and Class A/Class B GPCR mobilization.
Academic Article Arrestins as regulators of kinases and phosphatases.
Academic Article G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor.
Academic Article Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.
Academic Article Mitogenic signaling via G protein-coupled receptors.
Concept Protein-Tyrosine Kinases
Concept Protein Binding
Concept Protein Subunits
Concept Protein Transport
Concept Protein Processing, Post-Translational
Concept GTP-Binding Protein alpha Subunits, Gi-Go
Concept Mitogen-Activated Protein Kinases
Concept Calcium-Calmodulin-Dependent Protein Kinases
Concept Adaptor Protein Complex 2
Concept Mitogen-Activated Protein Kinase Kinases
Concept Oncogene Protein p21(ras)
Concept Protein Kinase Inhibitors
Concept Protein Phosphatase 2
Concept GTP-Binding Protein alpha Subunits, Gq-G11
Concept Mitogen-Activated Protein Kinase 1
Concept Ribosomal Protein S6 Kinases, 70-kDa
Concept GRB2 Adaptor Protein
Concept Protein Biosynthesis
Concept Receptors, G-Protein-Coupled
Concept Cyclic AMP-Dependent Protein Kinases
Concept Protein Kinases
Concept GTP-Binding Protein alpha Subunits, Gs
Concept Mitogen-Activated Protein Kinase 3
Concept G-Protein-Coupled Receptor Kinase 4
Concept Early Growth Response Protein 1
Concept Protein Structure, Secondary
Concept Ubiquitin-Protein Ligases
Concept Protein Kinase C
Concept Smad1 Protein
Concept Protein Structure, Tertiary
Concept Adaptor Protein Complex beta Subunits
Concept Receptor Protein-Tyrosine Kinases
Concept Cyclic AMP-Dependent Protein Kinase Type II
Concept Focal Adhesion Protein-Tyrosine Kinases
Concept Protein Sorting Signals
Concept GTP-Binding Protein Regulators
Concept Protein Isoforms
Concept Protein Conformation
Academic Article Arrestin-dependent activation of ERK and Src family kinases.
Academic Article Minireview: More than just a hammer: ligand "bias" and pharmaceutical discovery.
Academic Article Epidermal growth factor-induced proliferation of collecting duct cells from Oak Ridge polycystic kidney mice involves activation of Na+/H+ exchanger.
Academic Article Arrestin-dependent angiotensin AT1 receptor signaling regulates Akt and mTor-mediated protein synthesis.
Academic Article Informatic deconvolution of biased GPCR signaling mechanisms from in vivo pharmacological experimentation.
Academic Article Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.
Academic Article Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics.
Academic Article The conformational signature of ?-arrestin2 predicts its trafficking and signalling functions.
Academic Article GPCR Signaling Rides a Wave of Conformational Changes.
Academic Article Translating in vitro ligand bias into in vivo efficacy.
Academic Article Regulator of G protein signaling 2 is a key regulator of pancreatic ?-cell mass and function.
Academic Article The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling.
Academic Article Manifold roles of ?-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.
Academic Article Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between ?-Arrestin Isoforms.
Academic Article Aging-related modifications to G protein-coupled receptor signaling diversity.
Academic Article ?-Arrestin2 is a critical component of the GPCR-eNOS signalosome.
Academic Article SnapShot: ?-Arrestin Functions.
Concept Protein Interaction Maps
Concept Zonula Occludens-1 Protein
Concept Protein Kinase C beta
Concept ELAV-Like Protein 1
Concept Src Homology 2 Domain-Containing, Transforming Protein 1
Concept ADAM17 Protein
Concept Protein Domains
Search Criteria
  • Protein C